Aminobenzoic acids and derivatives
Selleck Chemical LLC A-1210477
A-1210477 is a potent and selective MCL-1 inhibitor with Ki and IC50 of 0 454 nM and 26 2 nM respectively 100-fold selectivity over other Bcl-2 family members
Apexbio Technology LLC KB-R7943 mesylate 182004-65-5 10mM (in 1mL DMSO)
KB-R7943 mesylate (CAS 182004-65-5) is a selective inhibitor of the Na /Ca2 exchanger (NCX) particularly effective against its reverse mode It inhibits NCX-mediated Ca2 influx with an IC50 of 0 7 M In transfected Chinese hamster ovary (CHO) cells expressing NCX KB-R7943 suppresses exchanger activity at high intracellular Na concentrations In cultured rat forebrain neurons it attenuates Ca2 transients induced by glutamate NMDA kainate or KCl with IC50 values ranging from 2 9 to 8 2 M In in vivo studies KB-R7943 reduces endothelin-1 levels and mitigates acute renal dysfunction following ischemic injury This compound is widely utilized in studies investigating Na /Ca2 exchange and related calcium signaling pathways
Medchemexpress LLC N-acetyl-L-leucyl-L-glutamyl-L-valyl-L-aspartyl aldehyde | 402832-01-3 | 98.4% | 500.54 g/mol | C22H36N4O9 | 5 MG
Ac-LEVD-CHO is an aldehyde peptide inhibitor of caspase-4 (sequence Ac-Leu-Glu-Val-Asp-CHO) used in biochemical and cell-based studies to inhibit caspase-4 activity. It is provided as a purified research reagent suitable for laboratory assays and mechanistic studies.
- Peptide aldehyde inhibitor of caspase-4.
- Sequence Ac-Leu-Glu-Val-Asp-CHO.
- Purity 98.4%.
- Molecular weight 500.54 g/mol.
- Soluble in DMSO and water.
- Available in small-mass vials for research use.
ACROTEIN CHEMBIO INC N FMOC R 2 AMINO 3 2 OXOPYR5G
N-Fmoc-(R)-2-amino-3-(2-oxopyrrolidin-1-yl)propanoic acid Q-20250808
Medchemexpress LLC Activin A Human/Mou 2ug
Activin A a multifunctional cytokine is a member of TGF- superfamily Activin A first binds to the type II activin receptors (ActIIRA or ActRIIB) on the member surface and then recruits and phosphorylates type I activin receptors (ActRI) Activin A primarily signal through SMAD2/3 proteins to regulate a variety of functions including inflammation fibrosis and tumorigenesis Activin A Protein Mouse (HEK293 His) is produced in HEK293 cells with a C-Terminal His-tag
Selleck Chemical LLC Danofloxacin Mesylate S3058-10mg
Danofloxacin (CP-76136-27) is a fluoroquinolone antibacterial for veterinary use with MIC90 of 0 28 M
Apexbio Technology LLC Bromocriptine mesylate 22260-51-1 10mM (in 1mL DMSO)
Bromocriptine mesylate (CAS 22260-51-1) is a selective agonist of D -like dopamine receptors exhibiting high affinity with a pKi of 8 05 0 2 Through modulation of D receptor activity bromocriptine mesylate influences metabolic processes by reducing glucose intolerance and insulin resistance inhibits pituitary prolactin secretion and enhances motor function relevant to Parkinson s disease The compound has established applications in research on metabolic disorders neuroendocrine regulation and neurodegenerative diseases including studies pertaining to type 2 diabetes prolactinomas acromegaly and Parkinson s disease
Apexbio Technology LLC Amino Tadalafil 385769-84-6 100mg
Amino Tadalafil (CAS 385769-84-6) is a small molecule that functions as a potent inhibitor of phosphodiesterase 5 (PDE5) an enzyme primarily expressed in the smooth muscle of the corpus cavernosum By structurally mimicking cGMP Amino Tadalafil competitively binds to PDE5 preventing the hydrolysis of cGMP and thereby enhancing nitric oxide-mediated vasodilation Preclinical studies have shown that Amino Tadalafil a structural analogue of tadalafil may be relevant for investigating mechanisms of erectile function and dysfunction It is also utilized in research evaluating PDE5 inhibitor adulteration in supplements and in animal models addressing erectile dysfunction associated with oxidative stress and spinal cord injury
Medchemexpress LLC Alpha-Ionone | 127-41-3 | MFCD00001565 | 192.30 | 1 ML
Alpha-Ionone (α-Ionone) is a chemical compound with the molecular formula C13H20O and a molecular weight of 192.30. It functions as an activator of the olfactory receptor OR10A6 and is known to induce apoptosis by stimulating the LATS-YAP-TAZ signaling axis within the Hippo pathway. This compound demonstrates inhibitory effects on tumor formation both in vitro and in vivo. It targets various pathways including Hippo (MST), YAP, Olfactory Receptor, and Apoptosis.
- Activates olfactory receptor OR10A6
- Induces apoptosis by activating LATS-YAP-TAZ signaling
- Inhibits tumor formation in vitro and in vivo
- Increases cAMP in A431 cells with an EC50 of 152.4 μM
- Inhibits proliferation and migration of A431 and HaCaT cells
- Modulates key proteins involved in apoptosis, including caspase-3, BAX, and BCL-2
- Suppresses growth of A431 cell xenograft in animal models